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Scientific Papers
Biomaterials/Bioresorbable Technology
To request additional copies of the literature listed below, please contact Kim Reiff: or Phone:
Orthopedics Supplement October 2002 Vol. 25 Number 10
The use of resorbable polymer implants in spinal applications: publication of 12 scientific journal papers. This supplement examines both preclinical and clinical evaluations of resorbable polymer implants fabricated from polylactide (PLa) as well as explores the future of theses implants and new resorbable design strategies.
Clinical Series in Bioresorbable Fixation
MacroPore Reconstruction System: Early Experience in Immediate Iliac Crest Contour Reconstruction
William Taylor, MD, Christopher Ames, MD, and Mauro M. Cataletto, MD.
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Preliminary results of postoperative pain level evaluation of nonreconstructed and reconstructed groups with iliac crest donor site defects after anterior and posterior graft procedures.
Case Study: Iliac Crest Reconstruction Utilizing MacroPore Reconstruction System
Mauro M. Cataletto, MD.
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This case study examines the results of reconstructing the iliac crest donor site with MacroPore Reconstruction System and evaluates reported benefits of preventing complications such as herniation, pain and discomfort, and cosmetic deformities.
Scientific Series in Bioresorbable Fixation
Protected Bone Regeneration
Ralph E. Holmes, MD, Stefan Lemperle, MD, and Christopher J. Calhoun, MBA.
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An examination of resorbable protective sheeting; its porosity for cellular exchange; prevention of interposition of adjacent soft tissues; and resorbable materials benefits compared to long-term issues associated with metallic implants. Its use is evaluated for graft containment, iliac crest reconstruction and secondary fixation for orthopedic fractures.
MacroPore Resorbable Technology: An Overview
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An examination of PLa vs PGA materials; analysis of PLa including biocompatibility, degradation and strength.
Animal Study Series in Bioresorbable Fixation
Protected Bone Regeneration in an Iliac Crest Animal Model
G. Bryan Cornwall, PhD, Kevin A. Thomas, PhD, A. Simon Turner, BVSc, MS, Dipl. ACVS, William R. Taylor, MD, and Donna L. Wheeler, PhD.
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Analysis of bone regeneration improvement, within the donor site following tricortical iliac crest graft harvesting in an adult ovine model, using MacroPore resorbable protective sheet to reconstruct the iliac crest.
Biologics/Stem Cell Technology
Stem Cells: A Primer
National Institutes of Health; May 2000
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This primer presents background information on stem cells. It includes a definition of stem cells and how they are derived; why stem cells are important to science; and why they hold such great promise for advances in health care.
Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies
Tissue Engineering, Volume 7, Number 2, 2001
Patricia A. Zuk, Ph.D., Min Zhu, M.D., Hiroshi Mizuno, M.D., Jerry Huang, B.S., J. William Futrell, M.D., Adam J. Katz, M.D., Prosper Benhaim, M.D., H. Peter Lorenz, M.D., and Marc H. Hedrick, M.D.
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Human adipose tissue, obtained by suction-assisted lipectomy (i.e., liposuction), was processed to obtain a fibroblast-like population of cells or a processed lipoaspirate (PLA). The data support the hypothesis that human lipoaspirate contains multipotent cells and represents an ideal stem cell source for tissue regeneration.
Myogenic Differentiation by Human Processed Lipoaspirate Cells
Plastic and Reconstructive Surgery; January 2002
Hiroshi Mizuno, M.D., Patricia A. Zuk, Ph.D., Min Zhu, M.D., H. Peter Lorenz, M.D., Prosper Benhaim, M.D., and Marc H. Hedrick, M.D.
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The authors have previously shown that cells isolated from raw human lipoaspirate display multilineage mesodermal potential in vitro. Findings from this study show that human processed lipoaspirate cells differentiate into myogenic cells. Furthermore, these cells may be a useful source for skeletal muscle engineering and repair.
The Evolving Concept of a Stem Cell: Entity or Function?
Cell Review, Vol. 105, June 2001
H.M. Blau, T.R. Brazelton, and J. M. Weimann; Department of Molecular Pharmacology, Stanford University School of Medicine
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Recent findings suggest that stem cell biology may be more complex than originally anticipated. The discovery that stem cells in adults can first reside in one tissue and then contribute to another suggests a previously unrecognized degree of plasticity in stem cell function.
Adult Stem Cells Promise for Improved Health
John K. Fraser, Ph.D., Marc H. Hedrick, M.D.
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Discussion of adult stem cells and potential uses to treat disorders and diseases. Reviews the challenges of sourcing stem cells, StemSource research, and benefits of adipose derived stem cells.
Stem Cells and Aging
John K. Fraser, Ph.D.
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Reviews the effects of aging on stem cell activity (stem cell number and functional integrity) in both human and animal models. Published and internal data show age-dependent decline in both proliferation and differentiation potential. Additionally, Dr. Fraser provides a review of NIH comments on the potential for stem cell therapies to address age-related illness and disease.
Recent Clinical Studies in Adult Stem Cells
John K. Fraser, Ph.D.
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A review of current studies using adult stem cells from various sources, in the following areas: cardiology, bone fracture, genetic bone disease, spinal cord injury, hepatology, and pancreatic cell function.
The Science of Stem Cell Banking
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Discussion of the rationale for banking stem cells and the technology employed. Provides a detailed description of all banking stages: collection, shipping, processing, cryopreservation and storage.
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